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Overview of HPV associated Low grade squamous intraepithelial lesion

Low grade squamous intraepithelial lesion(LSIL or LGSIL) indicates possible cervical dysplasia. LSIL usually indicates mild dysplasia (CIN 1), more than likely caused by a human papillomavirus infection. It is usually diagnosed following a Pap smear.CIN 1 is the most common and most benign form of cervical intraepithelial neoplasia and usually resolves spontaneously within two years. Because of this, LSIL results can be managed with a simple "watch and wait" philosophy. However, because there is a 12–16% chance of progression to more severe dysplasia, the physician may want to follow the results more aggressively by performing a colposcopy with biopsy.If the dysplasia progresses, treatment may be necessary. Treatment involves removal of the affected tissue, which can be accomplished by LEEP, cryosurgery, cone biopsy, or laser ablation.


ID Literature Title Group
1 25889023 Association of human papillomavirus 16 E6 variants with cervical carcinoma and precursor lesions in women from Southern Mexico.
Mutation
2 33909391 Sequence variation analysis of the E1 and E2 genes of human papillomavirus type 16 in cervical lesions in women from the south of Poland.
Mutation
3 33238632 E6/E7 Sequence Diversity of High-Risk Human Papillomaviruses in Two Geographically Isolated Populations of French Guiana.
Mutation
4 31933750 Variant sublineages of human papillomavirus type 16 predispose women to persistent infection characterized by a sequence analysis of the E6, L1, and LCR regions.
Mutation
5 31906371 Analysis of Human Papillomavirus (HPV) 16 Variants Associated with Cervical Infection in Italian Women.
Mutation
6 31231420 Abundance of HPV L1 Intra-Genotype Variants With Capsid Epitopic Modifications Found Within Low- and High-Grade Pap Smears With Potential Implications for Vaccinology.
Mutation
7 30583341 Phylogeny and Classification of Human Papillomavirus (HPV)16 and HPV18 Variants Based on E6 and L1 genes in Tunisian Women with Cervical Lesions
Mutation
8 30578936 Identification of human papillomavirus type 16 variants circulating in the Calabria region by sequencing and phylogenetic analysis of HPV16 from cervical smears.
Mutation
9 27977741 Analysis of Sequence Variation and Risk Association of Human Papillomavirus 52 Variants Circulating in Korea.
Mutation
10 27801430 HPV16 E6 polymorphism and physical state of viral genome in relation to the risk of cervical cancer in women from the south of Poland.
Mutation
11 27610192 Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol's iodine (VIA/VILI) in Libreville, Gabon.
Mutation
12 11308254 Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix.
Mutation
13 25793187 Prevalence of human papillomavirus variants and genetic diversity in the L1 gene and long control region of HPV16, HPV31, and HPV58 found in North-East Brazil.
Mutation
14 25735347 Mutation detection of E6 and LCR genes from HPV 16 associated with carcinogenesis.
Mutation
15 24236186 Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.
Mutation
16 24150786 Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.
Mutation
17 23136059 Geographical distribution and oncogenic risk association of human papillomavirus type 58 E6 and E7 sequence variations.
Mutation
18 23124863 Codon 72 polymorphism of p53 and HPV type 16 E6 variants as risk factors for patients with squamous epithelial lesion of the uterine cervix.
Mutation
19 22911739 Characterization and whole genome analysis of human papillomavirus type 16 e1-1374^63nt variants.
Mutation
20 22001139 Human papillomaviruses 53 and 66: clinical aspects and genetic analysis.
Mutation
21 16960775 Human papillomavirus type 33 polymorphisms and high-grade squamous intraepithelial lesions of the uterine cervix.
Mutation
Contents
Description
Group Note
  • Mutation Tag: literature about this virus mutation and click the eye icon to see detail mutation information in literature
  • VIS-cistrome Tag: literature associated this virus integration and click the eye icon to see detail information of 3 cistrome factors (histone modification, transcription factor binding site and chromatin accessibility)