HIV VIS Detail Information

> This page shows VIS [4014004] detail information, including site information (chromosome, GRCh38 location, disease, sample, etc) and literature information.

Site Information

Literature Information

PubMed PMID	24968937
Published year	2014
Journal	Science (New York, N.Y.)
Title	HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.
Author	Maldarelli F,Wu X,Su L,Simonetti FR,Shao W,Hill S,Spindler J,Ferris AL,Mellors JW,Kearney MF,Coffin JM,Hughes SH
Evidence	HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.