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Mutation Information
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Mutation Site
|
A14L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpu |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
24465210
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2014 |
|
Journal
|
PLoS pathogens |
|
Title
|
Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. |
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Author
|
Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ |
|
Evidence
|
Mutant Vpus derived from NL4.3 with defects in tetherin counteraction (A14L), or both tetherin counteraction and CD4 downregulation (S52,56A and AW14,22LA) were included in each assay as negative controls.
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HIV Mutation Detail Information