|
Mutation Information
|
Mutation Site
|
A1758C |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
P |
|
Nucleotide_Mutation
|
N248H |
|
Relevant Drug
|
tenofovir (TDF) |
|
Country
|
Pakistan |
Literature Information
|
PubMed PMID
|
30285571
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2018 |
|
Journal
|
Viral immunology |
|
Title
|
Predictors of Therapeutic Outcome to Nucleotide Reverse Transcriptase Inhibitor in Hepatitis B Patients. |
|
Author
|
Aziz M,Aziz H,Waheed Y,Gill ML |
|
Evidence
|
We noted that nonresponder patients showed substitution asparagine to histidine in E motif at rt248 amino acid positions (rtN248H mutation; nucleotide substitution from A to C at 1758 bp position) (Fig. 4).
|
|
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HBV Mutation Detail Information