HBV Mutation Detail Information

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Mutation Information

Mutation Site	A1762T
Mutation Type	Nucleotide level
Gene/Protein/Region Type	BCP
Combined Mutation	bcp.G1764A+bcp.A1762T
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM)

Literature Information

PubMed PMID	16197491
Disease	Chronic hepatitis B
Published Year	2005
Journal	Alimentary pharmacology & therapeutics
Title	Clinical reactivation during lamivudine treatment correlates with mutations in the precore/core promoter and polymerase regions of hepatitis B virus in patients with anti-hepatitis B e-positive chronic hepatitis.
Author	Marrone A,Zampino R,Karayannis P,Cirillo G,Cesaro G,Guerrera B,Ricciotti R,del Giudice EM,Utili R,Adinolfi LE,Ruggiero G
Evidence	Core promoter': the double basic core promoter (A1762T/G1764A) variant was detected in seven of eight (87%) of group A and in one of five (20%; P=0.03) of group B1 and one of nine (11%; P=0.002) of group B2 patients.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation