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Mutation Information
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Mutation Site
|
A1762T |
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Mutation Type
|
Nucleotide level |
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Gene/Protein/Region Type
|
BCP |
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Combined Mutation
|
bcp.G1764A+bcp.A1762T |
Literature Information
|
PubMed PMID
|
32760388
|
|
Published Year
|
2020 |
|
Journal
|
Frontiers in microbiology |
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Title
|
Differences in HBV Replication, APOBEC3 Family Expression, and Inflammatory Cytokine Levels Between Wild-Type HBV and Pre-core (G1896A) or Basal Core Promoter (A1762T/G1764A) Mutants. |
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Author
|
Lau KCK,Joshi SS,Mahoney DJ,Mason AL,van Marle G,Osiowy C,Coffin CS |
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Evidence
|
HBV variants, particularly the G1896A pre-core (PC) and A1762T/G1764A basal core promoter (BCP) mutations, are established risk factors for cirrhosis and HCC, but the molecular biological basis is unclear.
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HBV Mutation Detail Information