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Mutation Information
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Mutation Site
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A1768T |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
|
BCP |
Literature Information
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PubMed PMID
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27473751
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Published Year
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2016 |
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Journal
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The Journal of general virology |
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Title
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Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient. |
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Author
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Nishizawa T,Hoshino T,Naganuma A,Kobayashi T,Nagashima S,Takahashi M,Takagi H,Okamoto H |
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Evidence
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However, in comparison to three other variants (FH_T1766C, FH_A1768T and FH_T1766C/A1768T) with wild-type nucleotide(s) at 1766 and/or 1768, the FH genome exhibited a 2.5–5-fold enhancement of viral replication by heightened pregenomic RNA synthesis and a 1.5–2.5-fold reduction in the hepatitis B e antigen (HBeAg) synthesis by the downregulation of the precore mRNA level.
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HBV Mutation Detail Information