HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181S
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204I+rt.A181S
Relevant Drug	adefovir (ADV);lamivudine (LAM);tenofovir (TDF);clevudine (L-FMAU);emtricitabine (FTC)

Literature Information

PubMed PMID	17713159
Disease	Chronic hepatitis B
Published Year	2007
Journal	Antiviral therapy
Title	A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Author	Karatayli E,Karayalçin S,Karaaslan H,Kayhan H,Türkyilmaz AR,Sahin F,Yurdaydin C,Bozdayi AM
Evidence	A novel mutation, A181S, in the reverse transcriptase gene leading to a conversion of W172C in the overlapping surface antigen gene was detected along with a M2041 mutation.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation