HBV Mutation Detail Information

> A181T Search Result

Mutation Information

Mutation Site	A181T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	adefovir (ADV)

Literature Information

PubMed PMID	18433023
Disease	Chronic hepatitis B
Published Year	2008
Journal	Hepatology (Baltimore, Md.)
Title	Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Author	Jonas MM,Kelly D,Pollack H,Mizerski J,Sorbel J,Frederick D,Mondou E,Rousseau F,Sokal E
Evidence	The rtA181T mutation was identified in three lamivudine treatment‐experienced subjects at baseline and week 48 in the ADV group; the effects of ADV on serum HBV DNA and ALT in these three subjects did not appear to differ markedly from the effects observed in other subjects.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation