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Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
s.W172*+rt.A181T |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
18537180
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound. |
|
Author
|
Warner N,Locarnini S |
|
Evidence
|
The rtA181T/sW172* variant has a secretory defect and exerts a dominant negative effect on wild-type HBV virion secretion.
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|
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HBV Mutation Detail Information