|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
20222172
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2010 |
|
Journal
|
World journal of gastroenterology |
|
Title
|
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application. |
|
Author
|
Zhao WF,Shao YL,Chen LY,Wu JH,Zhu YL,Gan JH,Xiong H |
|
Evidence
|
Among the 32 clinical patients, single rtA181 and rtN236T mutation and double rtA181T and rtN236T mutations were detected in 20 and 8, respectively, while ADV-resistant mutations in 6 (including, rtA181V/T mutation alone in 5 patients) and no associated mutations in 26.
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HBV Mutation Detail Information