|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B |
|
Relevant Drug
|
morphothiadin (GLS4);lamivudine (LAM);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
22668794
|
|
Published Year
|
2012 |
|
Journal
|
Antiviral therapy |
|
Title
|
In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. |
|
Author
|
Wang XY,Wei ZM,Wu GY,Wang JH,Zhang YJ,Li J,Zhang HH,Xie XW,Wang X,Wang ZH,Wei L,Wang Y,Chen HS |
|
Evidence
|
2 plasmids that contained one of three major ADV-resistant mutations (rtA181T, rtA181V and rtN236T) were treated with GLS4.
|
|
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HBV Mutation Detail Information