|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
adefovir (ADV);telbivudine (LDT);entecavir (ETV);tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
23301549
|
|
Published Year
|
2013 |
|
Journal
|
Journal of viral hepatitis |
|
Title
|
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains. |
|
Author
|
Herbers U,Amini-Bavil-Olyaee S,Mueller A,Luedde T,Trautwein C,Tacke F |
|
Evidence
|
Therefore, HBV constructs with wild type (WT) or adefovir-resistant rtN236T, rtA181V and rtA181T mutations, with or without concomitant PC or BCP mutations, were analysed in vitro using molecular assays.
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HBV Mutation Detail Information