|
Mutation Information
|
Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181T;s.W172L+rt.A181T;s.W172*+rt.A181T;rt.N236T+s.W172L+rt.A181T |
|
Genotype/Subtype
|
B;C;D |
|
Relevant Drug
|
tenofovir (TDF);adefovir (ADV) |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
24118725
|
|
Disease
|
HBV infection
|
|
Published Year
|
2014 |
|
Journal
|
Liver international : official journal of the International Association for the Study of the Liver |
|
Title
|
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D. |
|
Author
|
Liu Y,Miller MD,Kitrinos KM |
|
Evidence
|
METHODS: Full-length HBV isolates from patients infected with genotype B, C and D virus had rtA181T, rtA181V, rtN236T, rtA181T+rtN236T and rtA181V+rtN236T mutations introduced by site-directed mutagenesis.
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HBV Mutation Detail Information