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Mutation Information
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Mutation Site
|
A181T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M250L+rt.A181T+rt.L80V+rt.L80I+rt.M204I;rt.A181T+rt.L80V+rt.L80I+rt.M204I;rt.A181T+rt.L80V+rt.L80I+rt.M204V+rt.M204I;rt.A181T+rt.L180M+rt.M204V+rt.M204I |
|
Relevant Drug
|
lamivudine (LAM);telbivudine (LDT);adefovir dipivoxil (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
24160943
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2013 |
|
Journal
|
Virology journal |
|
Title
|
Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B. |
|
Author
|
Lei J,Wang Y,Wang LL,Zhang SJ,Chen W,Bai ZG,Xu LY |
|
Evidence
|
Recently, HBV rtA181T/V mutations had been widely concerned and it was regarded to be a multidrug resistance which not only could result in resistance to ADV but also reduce sensitivity to LAM and LdT.
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HBV Mutation Detail Information