|
Mutation Information
|
Mutation Site
|
A181V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181V |
|
Relevant Drug
|
tenofovir (TDF);adefovir (ADV);clevudine (CLV) |
Literature Information
|
PubMed PMID
|
17591025
|
|
Published Year
|
2007 |
|
Journal
|
Antiviral therapy |
|
Title
|
In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents. |
|
Author
|
Qi X,Xiong S,Yang H,Miller M,Delaney WE 4th |
|
Evidence
|
Hepatitis B virus (HBV) polymerase mutations associated with virological breakthrough to ADV include rtA181V and rtN236T, which occur alone or in combination.
|
|
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HBV Mutation Detail Information