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Mutation Information
|
Mutation Site
|
A186A |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
30202825
|
|
Disease
|
HBV infection
|
|
Published Year
|
2018 |
|
Journal
|
Hepatology communications |
|
Title
|
Discovery of the Novel Entecavir-Resistant Hepatitis B Virus Reverse Transcriptase A181C Substitution From an Integrated Genotypic Analysis. |
|
Author
|
Rose RE,Hernandez D,Falk PJ,Ericson K,Zhou N,Thiry A,McPhee F |
|
Evidence
|
By contrast, the other patient experienced a virologic breakthrough harboring the novel substitutions rtF88F/Y, rtT184A/S, rtA186A/T, and rtF201F/Y, with LVDr substitutions L180M+M204V that persisted on ETV treatment.
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HBV Mutation Detail Information