HIV Mutation Detail Information

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Mutation Information

Mutation Site	A49G
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN
Relevant Drug	INSTIs
Country	US

Literature Information

PubMed PMID	31617907
Disease	HIV infection/AIDS
Published Year	2020
Journal	The Journal of antimicrobial chemotherapy
Title	Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.
Author	Tzou PL,Rhee SY,Descamps D,Clutter DS,Hare B,Mor O,Grude M,Parkin N,Jordan MR,Bertagnolio S,Schapiro JM,Harrigan PR,Geretti AM,Marcelin AG,Shafer RW,WHO HIVResNet Working Groups.
Evidence	Figure 2 shows that of the 59 INSTI-resistance mutations, 25 frequently co-occurred with one or more other mutations, including 20 non-polymorphic INSTI-selected mutations (H51Y, E92Q, H114Y, E138A/K/T, G140A/C/S, Y143C/H/R/S, S147G, Q148H/K/R, N155H, S230R and R263K), 3 polymorphic INSTI-selected mutations (L74M, T97A and D232N) and 2 rare mutations (A49G and Y143G).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation