HIV Mutation Detail Information

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Mutation Information

Mutation Site	A50T
Mutation Type	Amino acid level
Gene/Protein/Region Type	Vpu
Country	USA

Literature Information

PubMed PMID	24465210
Disease	HIV infection/AIDS
Published Year	2014
Journal	PLoS pathogens
Title	Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.
Author	Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ
Evidence	These mapped to three conserved residues: G59 and E62 in the second alpha helix of the cytoplasmic domain, and R45 in the first alpha helix. A cluster of Vpus had defects that mapped to A50V or -T changes, which accounted for the suboptimal activity of the majority of Vpus isolated from NP1 (Figure 6).

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation