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Mutation Information
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Mutation Site
|
A529T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
P |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
10827158
|
|
Disease
|
HBV infection
|
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Published Year
|
2000 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Clearance of the original hepatitis B virus YMDD-motif mutants with emergence of distinct lamivudine-resistant mutants during prolonged lamivudine therapy. |
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Author
|
Yeh CT,Chien RN,Chu CM,Liaw YF |
|
Evidence
|
Of them, 3 developed an alanine 529-to-threonine (A529T) mutant, 6 developed a leucine 528-to-methionine/methionine 552-to-isoleucine (L528M/M552I) mutant, and 1 developed these two mutants sequentially.
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HBV Mutation Detail Information