|
Mutation Information
|
Mutation Site
|
A741G |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Nucleotide_Mutation
|
M204V |
|
Genotype/Subtype
|
A |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
18171343
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. |
|
Author
|
Bottecchia M,Ikuta N,Niel C,Araujo NM,O KM,Gomes SA |
|
Evidence
|
In 2004 this motif was replaced by the YVDD motif, due to a (A to G) substitution at nucleotide 741 (which also causes a substitution Ile to Met at position 195 of the small S protein).
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HBV Mutation Detail Information