|
Mutation Information
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Mutation Site
|
C22S |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
L2 |
|
Genotype/Subtype
|
HPV16 |
Literature Information
|
PubMed PMID
|
19214230
|
|
Published Year
|
2009 |
|
Journal
|
PloS one |
|
Title
|
Two highly conserved cysteine residues in HPV16 L2 form an intramolecular disulfide bond and are critical for infectivity in human keratinocytes. |
|
Author
|
Campos SK,Ozbun MA |
|
Evidence
|
Single C22S and C28S and the double C22/28S mutants were non-infectious but had no apparent defects in cell binding, endocytosis, or trafficking to lysosomes by 8 h post infection.
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HPV Mutation Detail Information