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Mutation Information
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Mutation Site
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C345A |
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Mutation Type
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Nucleotide level |
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Gene/Protein/Region Type
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S |
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Combined Mutation
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s.C380T+s.C345A |
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Viral Reference
|
HM358335.1
|
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Country
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Iran |
Literature Information
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PubMed PMID
|
27381922
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Clinical information
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Yes
|
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Disease
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HBV-HIV coinfection
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Published Year
|
2017 |
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Journal
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Journal of medical virology |
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Title
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HBsAg mutations related to occult hepatitis B virus infection in HIV-positive patients result in a reduced secretion and conformational changes of HBsAg. |
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Author
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Sadeghi A,Shirvani-Dastgerdi E,Tacke F,Yagmur E,Poortahmasebi V,Poorebrahim M,Mohraz M,Hajabdolbaghi M,Rasoolinejad M,Abbasian L,Jafari R,Fakhari Z,Norouzi M,Ebrahimian A,Geravand B,Alavian SM,Jazayeri SM |
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Evidence
|
Two groups of mutations became apparent. In one group, all cases with C345A had C380T; and in the other group, C379A was accompanied by C407A. Deduced amino acid translation revealed that these groups had sP127L and sP127T + sS136Y amino acid substitutions, respectively.
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HBV Mutation Detail Information