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Mutation Information
|
Mutation Site
|
C69* |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
S |
|
Combined Mutation
|
s.C69*+s.I68T;s.C69*+s.I68T+s.F8L;s.C69*+s.I68T+s.G50D;s.C69L+s.I68T;s.C69*+s.I68T+s.N3S |
|
Viral Reference
|
AY741797.1
|
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
28392234
|
|
Disease
|
HBV infection
|
|
Published Year
|
2017 |
|
Journal
|
Journal of hepatology |
|
Title
|
Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy. |
|
Author
|
Shirvani-Dastgerdi E,Winer BY,Celià-Terrassa T,Kang Y,Tabernero D,Yagmur E,Rodríguez-Frías F,Gregori J,Luedde T,Trautwein C,Ploss A,Tacke F |
|
Evidence
|
RESULTS: Sequencing analyses revealed the selection of the rtS78T HBV polymerase mutation in both cases that simultaneously creates a premature stop codon at sC69 and thereby deletes almost the entire small HBV surface protein.
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|
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HBV Mutation Detail Information