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Mutation Information
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Mutation Site
|
C7294T |
|
Mutation Type
|
Nucleotide level |
|
Gene/Protein/Region Type
|
LCR |
|
Genotype/Subtype
|
HPV16 |
|
Viral Reference
|
K02718.1
|
|
Country
|
China |
Literature Information
|
PubMed PMID
|
24099556
|
|
Disease
|
Cervical intraepithelial neoplasia;
Cervical carcinoma
|
|
Published Year
|
2013 |
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Journal
|
BMC cancer |
|
Title
|
Genetic variations of E6 and long control region of human papillomavirus type 16 from patients with cervical lesion in Liaoning, China. |
|
Author
|
Sun Z,Lu Z,Liu J,Wang G,Zhou W,Yang L,Liu C,Wang B,Ruan Q |
|
Evidence
|
The EUR lineage variants showed a negative trend of association with the severity of ≥CIN2,3. Among 41 variations found in LCR, 25 (61.0%) were located at the binding sites for transcription factors. Occurrence of ≥CIN2,3 was significantly associated with the mutations of R10G/L83V in E6 and the C7294T co-variation in LCR, after adjusting for ages of infected patients.
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HPV Mutation Detail Information