HIV Mutation Detail Information

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Mutation Information

Mutation Site	D116A
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	19014595
Published Year	2008
Journal	Retrovirology
Title	Contribution of the C-terminal region within the catalytic core domain of HIV-1 integrase to yeast lethality, chromatin binding and viral replication.
Author	Xu Z,Zheng Y,Ao Z,Clement M,Mouland AJ,Kalpana GV,Belhumeur P,Cohen EA,Yao X
Evidence	Previous studies have indicated that the catalytic activity of IN may be required for IN-induced lethality in yeast since introduction of an IN catalytic mutant (D116A) was not lethal in the yeast strain AB2.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation