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HIV Mutation Detail Information

> D116A Search Result


Mutation Information
Mutation Site D116A
Mutation Type Amino acid level
Gene/Protein/Region Type PR
Literature Information
PubMed PMID 33093566
Published Year 2020
Journal Scientific reports
Title Nanoscale flow cytometry reveals interpatient variability in HIV protease activity that correlates with viral infectivity and identifies drug-resistant viruses.
Author Bonar MM,Tabler CO,Haqqani AA,Lapointe LE,Galiatsos JA,Joussef-Piña S,Quiñones-Mateu ME,Tilton JC
Evidence The D116A and E152E mutations in the catalytic site of IN have been reported to result in altered morphology of virions by electron microscopy, suggesting a defect in PR-mediated Gag polyprotein processing and viral maturation.
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation