|
Mutation Information
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Mutation Site
|
D174K |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Nef |
Literature Information
|
PubMed PMID
|
31186327
|
|
Published Year
|
2019 |
|
Journal
|
mBio |
|
Title
|
Potent Enhancement of HIV-1 Replication by Nef in the Absence of SERINC3 and SERINC5. |
|
Author
|
Wu Y,Olety B,Weiss ER,Popova E,Yamanaka H,Göttlinger H |
|
Evidence
|
We also tested the effect of a lysine substitution at position 174 of Nef (D174K), which has been reported to completely disrupt CD4 downregulation without compromising Nef expression or its ability to affect T cell receptor signaling.
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HIV Mutation Detail Information