HIV Mutation Detail Information

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Mutation Information

Mutation Site	D185G
Mutation Type	Amino acid level
Gene/Protein/Region Type	Gp120
Viral Reference	K03455.1

Literature Information

PubMed PMID	24758333
Published Year	2014
Journal	Retrovirology
Title	Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01_AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site.
Author	Utachee P,Isarangkura-na-ayuthaya P,Tokunaga K,Ikuta K,Takeda N,Kameoka M
Evidence	In order to confirm the role of the amino acid substitution at position 185 in viral neutralization susceptibility to b12, a mutation, D185G, was introduced into 47PL1-N197Q, a b12-susceptible AE-Env mutant, and its effect on viral b12 susceptibility was tested.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation