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Mutation Information
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Mutation Site
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D25N |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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PR |
Literature Information
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PubMed PMID
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32824587
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Published Year
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2020 |
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Journal
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International journal of molecular sciences |
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Title
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Y44A Mutation in the Acidic Domain of HIV-2 Tat Impairs Viral Reverse Transcription and LTR-Transactivation. |
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Author
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Szojka Z,Mótyán JA,Miczi M,Mahdi M,Tőzsér J |
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Evidence
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This was expected, since GFP expression in the HIV-2-CRU5SIN-CGW is driven under a CMV (cytomegalovirus) promoter. A virus carrying an inactivating mutation at the active site of the protease (D25N) was used as a negative control, which resulted in a complete abolishment of viral infectivity (Figure S2).
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HIV Mutation Detail Information