|
Mutation Information
|
Mutation Site
|
D29G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
C |
|
Genotype/Subtype
|
D |
|
Viral Reference
|
V01460
|
Literature Information
|
PubMed PMID
|
28647474
|
|
Published Year
|
2017 |
|
Journal
|
Antiviral research |
|
Title
|
Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro. |
|
Author
|
Berke JM,Tan Y,Verbinnen T,Dehertogh P,Vergauwen K,Vos A,Lenz O,Pauwels F |
|
Evidence
|
Combined analyses of clinical isolates and SDMs identified aa changes at positions 29, 33 and 118 led to reduced antiviral activity of BAY41-4109 with fold changes in EC50 values of 6, 46, and 9 for D29G, T33N, and Y118F, respectively.
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HBV Mutation Detail Information