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Mutation Information
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Mutation Site
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D325E |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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Env |
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Viral Reference
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K03455.1
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Immune Escape
|
Y |
Literature Information
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PubMed PMID
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30709739
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Published Year
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2019 |
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Journal
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Immunity |
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Title
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An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes. |
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Author
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Dingens AS,Arenz D,Weight H,Overbaugh J,Bloom JD |
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Evidence
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We validated the differential effects of mutations to site 325 by testing three different mutants at this site in TZM-bl neutralization assays: the maximal effect for 10-1074 was a 27-fold increase in IC50, while the maximal effect for PGT121 was just a 1.7-fold increase (D325E;Figure S3).
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HIV Mutation Detail Information