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Mutation Information

Mutation Site	E10R
Mutation Type	Amino acid level
Gene/Protein/Region Type	IN

Literature Information

PubMed PMID	25383358
Published Year	2014
Journal	Molecular therapy. Methods & clinical development
Title	Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.
Author	Wang H,Shun MC,Li X,Di Nunzio F,Hare S,Cherepanov P,Engelman A
Evidence	Similar differential transduction levels were observed for each of the novel mutant viruses;as RR (E10R/E13R) and KR (E10K/E13R) would require six and four nucleotide changes, respectively, to revert to the WT sequence, they were earmarked for virus evolution.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation