HIV Mutation Detail Information

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Mutation Information

Mutation Site	E138A
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	NNRTIs
Country	Scotland

Literature Information

PubMed PMID	32877546
Disease	HIV infection/AIDS
Published Year	2020
Journal	The Journal of infectious diseases
Title	From Hospital to the Community: Redesigning the Human Immunodeficiency Virus (HIV) Clinical Service Model to Respond to an Outbreak of HIV Among People Who Inject Drugs.
Author	Metcalfe R,Ragonnet-Cronin M,Bradley-Stewart A,McAuley A,Stubbs H,Ritchie T,O'Hara R,Trayner K,Glover C,Laverty L,Sills L,Brown K,Gunson R,Campbell J,Milsoevic C,Anderson P,Peters SE
Evidence	Phylogenetic analysis demonstrated that this strain of subtype C virus, with primary nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations E138A and V179E, had been transmitted recently and rapidly among Scottish PWID but had not yet spread anywhere else in the UK.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation