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Mutation Information
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Mutation Site
|
E138G |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Genotype/Subtype
|
CRF01_B |
|
Viral Reference
|
AF503396;
JF906665;
HQ215583;
JQ901027;
JQ901094;
EF122515;
AY008714;
U51189;
JF906597;
JQ028206;
AF286229;
AY008717;
K03455;
U71182;
KF857447;
AY358072;
KC183783;
X52154 |
|
Relevant Drug
|
efavirenz (EFV);etravirine(ETR);rilpivirine (RPV);nevirapine (NPV) |
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Country
|
China |
Literature Information
|
PubMed PMID
|
28622345
|
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Disease
|
HIV infection/AIDS
|
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Published Year
|
2017 |
|
Journal
|
PloS one |
|
Title
|
The infection staging and profile of genotypic distribution and drug resistance mutation among the human immunodeficiency virus-1 infected blood donors from five Chinese blood centers, 2012-2014. |
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Author
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Zeng P,Liu Y,He M,Wang J,Keating S,Mao W,Huang M,Ma H,He W,Bi X,Liao D,Busch M,Ness P,Liu J,Shan H,NHLBI Recipient Epidemiology and Donor Evaluation Study-III program. |
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Evidence
|
While one male donor (Specimen ID: LY12004233) from Luoyang with HIV recent infection bears high-level resistance (HLR) to efavirenz (EFV), nevirapine (NVP) and RPV and intermediate-level resistance (ILR) to ETR due to mutation of E138G and G190E.
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HIV Mutation Detail Information