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Mutation Information
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Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
INSTIs |
|
Country
|
Cameroon |
Literature Information
|
PubMed PMID
|
32843050
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2020 |
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Journal
|
Antimicrobial resistance and infection control |
|
Title
|
First case of Dolutegravir and Darunavir/r multi drug-resistant HIV-1 in Cameroon following exposure to Raltegravir: lessons and implications in the era of transition to Dolutegravir-based regimens. |
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Author
|
Fokam J,Takou D,Semengue ENJ,Teto G,Beloumou G,Dambaya B,Santoro MM,Mossiang L,Billong SC,Cham F,Sosso SM,Temgoua ES,Nanfack AJ,Moudourou S,Kamgaing N,Kamgaing R,Ngako Pamen JN,Etame MMN,Bissek AZ,Elat JN,Moussi EE,Colizzi V,Perno CF,Ndjolo A,VIROFORUM. |
|
Evidence
|
Another GRT, covering HIV-1 integrase (IN) region, performed on the sample plasma aliquot, revealed major RAMs, L74I, E138KQ, G140A, Q148R, and E157Q, to integrase strand transfer inhibitors (INSTI) including raltegravir, dolutegravir, bictegravir and elvitegravir.
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HIV Mutation Detail Information