|
Mutation Information
|
Mutation Site
|
E138K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
NNRTIs |
Literature Information
|
PubMed PMID
|
33895602
|
|
Published Year
|
2021 |
|
Journal
|
Bioorganic chemistry |
|
Title
|
Chemical space exploration of novel naphthyl-carboxamide-diarylpyrimidine derivatives with potent anti-HIV-1 activity. |
|
Author
|
Sang Y,Pannecouque C,De Clercq E,Zhuang C,Chen F |
|
Evidence
|
They displayed up to single-digit nanomolar activity against wild-type (WT) and rilpivirine-associated resistant mutant E138K viruses, as well as potent inhibitory ability toward the RT enzyme.
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HIV Mutation Detail Information