|
Mutation Information
|
Mutation Site
|
E29K |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Vpu |
|
Country
|
USA |
Literature Information
|
PubMed PMID
|
24465210
|
|
Disease
|
HIV infection/AIDS
|
|
Published Year
|
2014 |
|
Journal
|
PLoS pathogens |
|
Title
|
Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals. |
|
Author
|
Pickering S,Hué S,Kim EY,Reddy S,Wolinsky SM,Neil SJ |
|
Evidence
|
Of these, an E29K mutant that was defective for both tetherin counteraction and CD4 downregulation was highly active in suppressing both tetherin and MAVS-mediated NF-κB activation.
|
|
|
HIV Mutation Detail Information