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Mutation Information
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Mutation Site
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E326Q |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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LMP1 |
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Country
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Japanese |
Literature Information
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PubMed PMID
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16917737
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Disease
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NK/T cell lymphoma
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Published Year
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2007 |
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Journal
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Virus genes |
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Title
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Sequence variations of Epstein-Barr virus LMP1 gene in nasal NK/T-cell lymphoma. |
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Author
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Nagamine M,Takahara M,Kishibe K,Nagato T,Ishii H,Bandoh N,Ogino T,Harabuchi Y |
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Evidence
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The amino acid changes at codon 309 (Ser to Asn), 322 (Gln to Asn) and 326 (Glu to Gln), were found in all, 6 (86%) and 3 (43%) of 7 patients, respectively. In addition, the amino acid Table 1 The sequences and coordinates of PCR primers Transcript Primersa Sequence (5-3) B95-8 genomic coordinates LMP1 1S (s) CTTTCCTCAACTGCCTTGCT 169514169495 1MS (s) ATTATTGCTCTCTATCTACAACAA 168858168835 1ME (as) TCATCACTGTGTCGTTGTCC 168740168759 1E (as) TCCCAGTAAATGGAGGGAGAGTCA 168091168114 a The sense (s) or antisense (as) orientation is indicated in brackets Virus Genes (2007) 34:4754 49 123 change at codon 322 (Gln to Thr), 328 (Glu to Asp) and 329 (Asn to His) were detected in each one patient.
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EBV Mutation Detail Information