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Mutation Information
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Mutation Site
|
E345A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Tax |
Literature Information
|
PubMed PMID
|
25340740
|
|
Published Year
|
2014 |
|
Journal
|
PLoS pathogens |
|
Title
|
HTLV-1 tax stabilizes MCL-1 via TRAF6-dependent K63-linked polyubiquitination to promote cell survival and transformation. |
|
Author
|
Choi YB,Harhaj EW |
|
Evidence
|
Tax promoted the K63-linked autoubiquitination of TRAF6, however TaxM22 and TaxE345A mutants were both impaired in inducing the TRAF6 autoubiquitination (Figure 2A).
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HTLV1 Mutation Detail Information