|
Mutation Information
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Mutation Site
|
E478Q |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.E478Q+rt.T215Y+rt.M41L |
|
Relevant Drug
|
3'-azido-3'-deoxythymidine |
Literature Information
|
PubMed PMID
|
32747359
|
|
Published Year
|
2020 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Nucleocapsid Protein Precursors NCp9 and NCp15 Suppress ATP-Mediated Rescue of AZT-Terminated Primers by HIV-1 Reverse Transcriptase. |
|
Author
|
Árquez MA,Martín-Alonso S,Gorelick RJ,Scott WA,Acosta-Hoyos AJ,Menéndez-Arias L |
|
Evidence
|
RNase H inactivation by introducing the active-site mutation E478Q led to the loss of the inhibitory effect shown by NCp9.
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HIV Mutation Detail Information