HBV Mutation Detail Information

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Mutation Information

Mutation Site	E77Q
Mutation Type	Amino acid level
Gene/Protein/Region Type	C

Literature Information

PubMed PMID	16378961
Published Year	2006
Journal	Journal of virology
Title	Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression.
Author	Guarnieri M,Kim KH,Bang G,Li J,Zhou Y,Tang X,Wands J,Tong S
Evidence	Since the E77Q mutation present in the core gene of N4-based constructs greatly reduces the sensitivity of HBeAg detection by a commercial polyclonal antibody (Dako) (K. Kim and S. Tong, unpublished), we introduced a Q77E mutation back into these constructs.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation