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Mutation Information
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Mutation Site
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E89G |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Relevant Drug
|
NRTIs |
Literature Information
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PubMed PMID
|
16207371
|
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Published Year
|
2005 |
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Journal
|
AIDS research and therapy |
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Title
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HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors. |
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Author
|
Fisher TS,Joshi P,Prasad VR |
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Evidence
|
In contrast, mutations shown to confer resistance to multiple NRTIs, including E89G, K65R and M184V displayed low levels of resistance to RT1t49 (2-5 fold), with K65R displaying the highest level of resistance (5-fold).
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HIV Mutation Detail Information