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Mutation Information
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Mutation Site
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E96A |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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IN |
Literature Information
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PubMed PMID
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32960169
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Published Year
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2020 |
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Journal
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eLife |
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Title
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Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. |
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Author
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Elliott JL,Eschbach JE,Koneru PC,Li W,Puray-Chavez M,Townsend D,Lawson DQ,Engelman AN,Kvaratskhelia M,Kutluay SB |
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Evidence
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With the exception of E96A, nearly all of the IN substitutions reduced virus titers at least 100-fold compared to the WT (Figure 2B), which corresponded with reduced levels of reverse-transcription in infected cells (Figure 2C).
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HIV Mutation Detail Information