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Mutation Information
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Mutation Site
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F116Y |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
Literature Information
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PubMed PMID
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30029500
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Published Year
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2018 |
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Journal
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Viruses |
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Title
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The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations. |
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Author
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Maldonado JO,Mansky LM |
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Evidence
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In particular, A62V was observed in various multi-dideoxynucleoside resistant (MDR) mutation complexes, including the Q151M complex (i.e., A62V, V75I, F77L, F116Y, and Q151M), and the T69SSS insertion complex, which has a serine-serine insertion between amino acid positions 69 and 70 (i.e., M41L, A62V, T69SSS, K70R, and T215Y).
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HIV Mutation Detail Information