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Mutation Information
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Mutation Site
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F227V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
Literature Information
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PubMed PMID
|
32082978
|
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Published Year
|
2020 |
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Journal
|
Acta pharmaceutica Sinica. B |
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Title
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Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. |
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Author
|
Jin K,Liu M,Zhuang C,De Clercq E,Pannecouque C,Meng G,Chen F |
|
Evidence
|
Compound 5j exhibited great activity against the viral, especially the double mutant strains of HIV-1 K103N/Y181C and F227L/V106A with EC50 values of 34 and 17 nmol/L, respectively.
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HIV Mutation Detail Information