HBV Mutation Detail Information

> F23A Search Result

Mutation Information

Mutation Site	F23A
Mutation Type	Amino acid level
Gene/Protein/Region Type	C

Literature Information

PubMed PMID	28205569
Published Year	2017
Journal	Scientific reports
Title	Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Author	Zhou Z,Hu T,Zhou X,Wildum S,Garcia-Alcalde F,Xu Z,Wu D,Mao Y,Tian X,Zhou Y,Shen F,Zhang Z,Tang G,Najera I,Yang G,Shen HC,Young JA,Qin N
Evidence	Y132A or F23A mutation is known to disrupt capsid formation. Placing a bulky function group like thiazole, HAP_R01 can induce local rearrangements at F23 and Y118 of the concave and the proline-rich loop 6 (P130, A131, Y132A) of the cap.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation