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MCV Mutation Detail Information

> F391A Search Result


Mutation Information
Mutation Site F391A
Mutation Type Amino acid level
Gene/Protein/Region Type Large T
Viral Reference EU375804.1
Literature Information
PubMed PMID 21501625
Published Year 2011
Journal Journal of molecular biology
Title Asymmetric assembly of Merkel cell polyomavirus large T-antigen origin binding domains at the viral origin.
Author Harrison CJ,Meinke G,Kwun HJ,Rogalin H,Phelan PJ,Bullock PA,Chang Y,Moore PS,Bohm A
Evidence When Phe 391 was mutated to alanine, no significant effect on protein-DNA affinity or stoichiometry could be measured by ITC (KD ~990 nM, n = 2.86) (Supplementary Figure 5A and Table I).
Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation