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Mutation Information
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Mutation Site
|
F519L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
Gp41 |
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Combined Mutation
|
gp41.V535M+gp41.F519L+gp41.M518V |
|
Relevant Drug
|
vicriviroc (VCV) |
Literature Information
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PubMed PMID
|
21356539
|
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Published Year
|
2011 |
|
Journal
|
Virology |
|
Title
|
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41. |
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Author
|
Anastassopoulou CG,Ketas TJ,Depetris RS,Thomas AM,Klasse PJ,Moore JP |
|
Evidence
|
12 variants contained at least one substitution in the gp120 V3 region (H308P), plus one of two patterns of gp41 sequence changes involving the fusion peptide (FP) and a downstream residue: G514V+V535M or M518V+F519L+V535M.
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HIV Mutation Detail Information