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Mutation Information
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Mutation Site
|
F69A |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
Vpr |
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Combined Mutation
|
vpr.F69A+vpr.R62D |
Literature Information
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PubMed PMID
|
33648539
|
|
Published Year
|
2021 |
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Journal
|
Virology journal |
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Title
|
HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7. |
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Author
|
Zhou X,Monnie C,DeLucia M,Ahn J |
|
Evidence
|
We previously showed that single R62D or F69A mutation affected Vpr interaction with DCAF1, respectively, and F69A mutation reduced Vpr-mediated Exo1 association with DDB1 and DCAF1.
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HIV Mutation Detail Information